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藥靶細胞株 > kinase激酶細胞株 > CBP73336PDGFRA V658A-R558_I565del/Baf3 細胞株

PDGFRA V658A-R558_I565del/Baf3 細胞株
名稱 PDGFRA V658A-R558_I565del/Baf3 細胞株
型號 CBP73336
報價
特點 PDGFRA V658A-R558_I565del/Baf3
  • 詳細內(nèi)容
CBP73336
I. Introduction
Cell Line Name:PDGFRA V658A-R558_I565del/Baf3
Host Cell:Ba/F3
Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:90% FBS+10% DMSO
Complete Culture Medium:RPMI-1640+10%FBS
Mycoplasma Status:Negative
II.Background

PDGFRA, platelet-derived growth factor receptor alpha, is a receptor tyrosine kinase that activates PI3K/Akt, RAS/MAPK, and JAK/STAT pathways to promote cell proliferation and survival (PMID: 21605429). PDGFRA mutations have been detected in melanoma, AML, peripheral nerve sheath tumors, sarcoma, and neuroendocrine carcinomas (PMID: 23752188, PMID: 20685895), several fusions have also been reported (PMID: 22432087, PMID: 26276769), and amplification has been observed in glioblastoma (PMID: 23438035).

III. Representative Data

1.Sanger of PDGFRA V658A-R558_I565del/Baf3

CBP73336 sanger-V658A 3WLSZ6TG)4CH)1]BTSQF3QJ.jpg


Figure 1. PDGFRA V658A-R558_I565del/Baf3 V658A

CBP73336 sanger-Del24 R[S%P0635}`[`JFP1REI95D.jpg


Figure 2. PDGFRA V658A-R558_I565del/Baf3 Del24



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